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Pharmaceutical Dosage Form and Drug Delivery System

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Introduction A drug delivery system or dosage form is defined as the various means through which a drug is made to reach the specific target site in the body to perform its therapeutic actions. It is designed in such a way as to facilitate the provision of the drug components to the target site. Why is dosage form required? The need for designing a dosage form arises for many reasons which are summarized as follows: To ensure the safe and easy delivery of the drug to the active site. To provide the accurate dosage of the drug. To protect a drug from the harmful atmospheric effects such as oxidation and moisture. Drugs vulnerable of being effected by harmful effects of atmosphere are coated with a suitable protective agent allowing it to retain its efficacy. To provide an insoluble or unstable drug in liquid preparation such as suspensions. To mask the bitter, salty or undesirable taste or odor of any drug components. To provide a soluble drug in liquid preparation such as solut...

Pharmaceutical Drug Formulation

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  The term used to define the process in pharmaceutical studies, involving the combination of chemical components, including the active drug and the excipients, for the production of a medicinal product, is known as formulation. The term formulation is sometimes also used to define a particular dosage form. Stages involved in the process of formulation: Study of pharmaceutical Drug Formulation involves the development of a preparation or formula of the drug that is the most stable and compatible with the patient's body, as well as fulfills the needs and therapeutic requirements of the patient.   The preparation of orally administered drugs usually involves the incorporation of drug material into a tablet or capsule. It is important to know that a tablet or capsule contains a number of chemical substances other than the active ingredient, and it is important to make sure that the compatibility of encapsulated drug with other components is in such a way that all the drug com...